abstract：:The concept of 'targeted' therapies implies that such drugs only act on cells that specifically express the particular target, therefore giving rise to a low incidence of side effects. However, targeted therapies currently approved for the treatment of breast cancer have demonstrated a relatively high incidence of car...

journal_title：Breast cancer research : BCR

authors： Criscitiello C,Metzger-Filho O,Saini KS,de Castro G Jr,Diaz M,La Gerche A,de Azambuja E,Piccart-Gebhart MJ

更新日期：2012-06-19 00:00:00

abstract：INTRODUCTION:Breast carcinoma is the most common cancer in women, but its incidence is not increased in Lynch syndrome (LS) and studies on DNA mismatch repair deficiency (MMR) in LS-associated breast cancers have arrived at conflicting results. This study aimed to settle the question as to whether breast carcinoma belo...

journal_title：Breast cancer research : BCR

authors： Lotsari JE,Gylling A,Abdel-Rahman WM,Nieminen TT,Aittomäki K,Friman M,Pitkänen R,Aarnio M,Järvinen HJ,Mecklin JP,Kuopio T,Peltomäki P

更新日期：2012-06-12 00:00:00

abstract：INTRODUCTION:Sustained HER2 signaling at the cell surface is an oncogenic mechanism in a significant proportion of breast cancers. While clinically effective therapies targeting HER2 such as mAbs and tyrosine kinase inhibitors exist, tumors overexpressing HER2 eventually progress despite treatment. Thus, abrogation of ...

journal_title：Breast cancer research : BCR

authors： Ren XR,Wei J,Lei G,Wang J,Lu J,Xia W,Spector N,Barak LS,Clay TM,Osada T,Hamilton E,Blackwell K,Hobeika AC,Morse MA,Lyerly HK,Chen W

更新日期：2012-06-07 00:00:00

abstract：INTRODUCTION:The re-emergence of the tumour growth factor-beta (TGF-beta)-related embryonic morphogen Nodal has recently been reported in several different human cancers. In this study, we examined the expression of Nodal in a series of benign and malignant human breast tissues to determine the clinical significance of...

journal_title：Breast cancer research : BCR

authors： Strizzi L,Hardy KM,Margaryan NV,Hillman DW,Seftor EA,Chen B,Geiger XJ,Thompson EA,Lingle WL,Andorfer CA,Perez EA,Hendrix MJ

更新日期：2012-05-11 00:00:00

abstract：INTRODUCTION:The chromodomain helicase DNA binding protein 5 (CHD5) has recently been identified as a tumor suppressor in a mouse model. The CHD5 locus at 1p36 is deleted, and its mutation has been detected in breast cancer. We, therefore, evaluated whether CHD5 plays a role in human breast cancer. METHODS:We screened...

journal_title：Breast cancer research : BCR

authors： Wu X,Zhu Z,Li W,Fu X,Su D,Fu L,Zhang Z,Luo A,Sun X,Fu L,Dong JT

更新日期：2012-05-08 00:00:00

abstract：INTRODUCTION:Pre-clinical data suggest p53-dependent anthracycline-induced apoptosis and p53-independent taxane activity. However, dedicated clinical research has not defined a predictive role for TP53 gene mutations. The aim of the current study was to retrospectively explore the prognosis and predictive values of TP5...

journal_title：Breast cancer research : BCR

authors： Fernández-Cuesta L,Oakman C,Falagan-Lotsch P,Smoth KS,Quinaux E,Buyse M,Dolci MS,Azambuja ED,Hainaut P,Dell'orto P,Larsimont D,Francis PA,Crown J,Piccart-Gebhart M,Viale G,Leo AD,Olivier M

更新日期：2012-05-02 00:00:00

abstract：INTRODUCTION:The neuron-glial antigen 2 (NG2) proteoglycan promotes pericyte recruitment and mediates pericyte interaction with endothelial cells. In the absence of NG2, blood vessel development is negatively impacted in several pathological models. Our goal in this study was to determine the effect of NG2 ablation on ...

journal_title：Breast cancer research : BCR

authors： Gibby K,You WK,Kadoya K,Helgadottir H,Young LJ,Ellies LG,Chang Y,Cardiff RD,Stallcup WB

更新日期：2012-04-24 00:00:00

abstract：INTRODUCTION:In response to gamma-irradiation (IR)-induced double-strand DNA breaks, cells undergo cell-cycle arrest, allowing time for DNA repair before reentering the cell cycle. G2/M checkpoint activation involves activation of ataxia telangiectasia mutated (ATM)/ATM- and rad3-related (ATR) kinases and inhibition of...

journal_title：Breast cancer research : BCR

authors： Yan Y,Greer PM,Cao PT,Kolb RH,Cowan KH

更新日期：2012-04-11 00:00:00

abstract：INTRODUCTION:With the improvement of therapeutic options for the treatment of breast cancer, the development of brain metastases has become a major limitation to life expectancy in many patients. Therefore, our aim was to identify molecular markers associated with the development of brain metastases in breast cancer. ...

journal_title：Breast cancer research : BCR

authors： Wikman H,Lamszus K,Detels N,Uslar L,Wrage M,Benner C,Hohensee I,Ylstra B,Eylmann K,Zapatka M,Sauter G,Kemming D,Glatzel M,Müller V,Westphal M,Pantel K

更新日期：2012-03-19 00:00:00

abstract：INTRODUCTION:Estrogen receptor-α (ER) and human epidermal growth factor receptor 2 (HER2) positivity are inversely correlated by standard criteria. However, we investigated the quantitative relation between ER and HER2 expression at both RNA and protein levels in HER2+ve and HER2-ve breast carcinomas. METHODS:ER and H...

journal_title：Breast cancer research : BCR

authors： Pinhel I,Hills M,Drury S,Salter J,Sumo G,A'Hern R,Bliss JM,Sestak I,Cuzick J,Barrett-Lee P,Harris A,Dowsett M,NCRI Adjuvant Breast Cancer Trial Management Group.

更新日期：2012-03-14 00:00:00

abstract：:PIK3CA mutations confer constitutive activation of PI3K, which initiates intracellular kinase signaling cascades that promote cell proliferation and survival. Recent studies by Meyer and colleagues, and Liu and colleagues demonstrate that expression of the H1047R exon 20 mutant of PIK3CA in luminal mammary epithelial ...

journal_title：Breast cancer research : BCR

authors： Miller TW

更新日期：2012-02-07 00:00:00

abstract：INTRODUCTION:Increased mammographic breast density is one of the strongest risk factors for breast cancer. While two-thirds of the variation in mammographic density appears to be genetically influenced, few variants have been identified. We examined the association of inherited variation in genes from pathways that med...

journal_title：Breast cancer research : BCR

authors： Vachon CM,Li J,Scott CG,Hall P,Czene K,Wang X,Liu J,Fredericksen ZS,Rider DN,Wu FF,Olson JE,Cunningham JM,Stevens KN,Sellers TA,Pankratz SV,Couch FJ

更新日期：2012-01-07 00:00:00

abstract：INTRODUCTION:Incidence of breast cancer is increasing around the world and it is still the leading cause of cancer mortality in low- and middle-income countries. We utilized Swedish nationwide registers to study breast cancer incidence and case fatality to disentangle the effect of socioeconomic position (SEP) and immi...

journal_title：Breast cancer research : BCR

authors： Beiki O,Hall P,Ekbom A,Moradi T

更新日期：2012-01-06 00:00:00

abstract：INTRODUCTION:Breast cancers frequently metastasise to the skeleton where they cause osteolytic bone destruction by stimulating osteoclasts to resorb bone and by preventing osteoblasts from producing new bone. The Runt-related transcription factor 2, Runx2, is an important determinant of bone metastasis in breast cancer...

journal_title：Breast cancer research : BCR

authors： Mendoza-Villanueva D,Zeef L,Shore P

更新日期：2011-10-27 00:00:00

abstract：:Advances in genotyping technology have provided us with a large number of genetic loci associated with cancer susceptibility; however, our ability to understand the functional effects of the genetic variants of these loci remains limited. In the previous issue, Smits and colleagues demonstrate the use of congenic rat ...

journal_title：Breast cancer research : BCR

authors： Blackburn AC

更新日期：2011-10-12 00:00:00

abstract：:The metastatic process is a multistep coordinated event with a high degree of efficiency. Specific subpopulations of cancer stem cells, with tumor-initiating and migratory capacity, can selectively migrate towards sites that are able to promote survival and/or proliferation of metastatic tumor cells through a microenv...

journal_title：Breast cancer research : BCR

authors： Santini D,Vincenzi B,Pantano F,Tonini G,Bertoldo F

更新日期：2011-08-16 00:00:00

abstract：:Preclinical investigations and selected clinical observational studies support an association between higher vitamin D intake and 25-hydroxyvitamin D levels with lower breast cancer risk. However, the recently updated report from the Institute of Medicine concluded that, for cancer and vitamin D, the evidence was 'inc...

journal_title：Breast cancer research : BCR

authors： Chlebowski RT

更新日期：2011-08-16 00:00:00

abstract：INTRODUCTION:The presence of tumor cells in the axillary lymph nodes is the most important prognostic factor in early stage breast cancer. However, the optimal method for sentinel lymph node (SLN) examination is still sought and currently many different protocols are employed. To examine two approaches for tumor cell d...

journal_title：Breast cancer research : BCR

authors： Tveito S,Andersen K,Kåresen R,Fodstad Ø

更新日期：2011-08-04 00:00:00

abstract：INTRODUCTION:The ataxia-telangiectasia mutated (ATM) gene (MIM ID 208900) encodes a protein kinase that plays a significant role in the activation of cellular responses to DNA double-strand breaks through subsequent phosphorylation of central players in the DNA damage-response pathway. Recent studies have confirmed tha...

journal_title：Breast cancer research : BCR

authors： Goldgar DE,Healey S,Dowty JG,Da Silva L,Chen X,Spurdle AB,Terry MB,Daly MJ,Buys SM,Southey MC,Andrulis I,John EM,BCFR.,kConFab.,Khanna KK,Hopper JL,Oefner PJ,Lakhani S,Chenevix-Trench G

更新日期：2011-07-25 00:00:00

abstract：INTRODUCTION:Metastasis is a common event and the main cause of death in cancer patients. Lymphangiogenesis refers to the formation of new lymphatic vessels and is thought to be involved in the development of metastasis. Sunitinib is a multi-kinase inhibitor that blocks receptor tyrosine kinase activity, including that...

journal_title：Breast cancer research : BCR

authors： Kodera Y,Katanasaka Y,Kitamura Y,Tsuda H,Nishio K,Tamura T,Koizumi F

更新日期：2011-06-21 00:00:00

abstract：INTRODUCTION:Human epidermal growth factor 2 (Her2), a receptor tyrosine kinase, is overexpressed in breast cancers. It has been successfully targeted by small molecule kinase inhibitors and by antibodies. Recent clinical data show a synergistic response in patients when two antibodies, trastuzumab and pertuzumab, are ...

journal_title：Breast cancer research : BCR

authors： Fuentes G,Scaltriti M,Baselga J,Verma CS

更新日期：2011-05-22 00:00:00

abstract：:Estrogen receptor α (ER) is a major driver of breast cancer and the target of endocrine therapy. Full disclosure of the cofactors regulating ER interactions with chromatin and its transcriptional regulatory activity is still elusive. Novel genome-wide profiling tools have mapped ER binding events in breast cancer cell...

journal_title：Breast cancer research : BCR

authors： Fu X,Huang C,Schiff R

更新日期：2011-04-20 00:00:00

abstract：INTRODUCTION:Inhibition of phosphatidylinositol-3-kinase (PI3K) induces apoptosis when combined with estrogen deprivation in estrogen receptor (ER)-positive breast cancer. The aims of the present study were to identify effective PI3K pathway inhibitor and endocrine therapy combinations, to evaluate the effect of PI3K p...

journal_title：Breast cancer research : BCR

authors： Sanchez CG,Ma CX,Crowder RJ,Guintoli T,Phommaly C,Gao F,Lin L,Ellis MJ

更新日期：2011-03-01 00:00:00

abstract：INTRODUCTION:We previously reported an association between tumor-specific 3-hydroxy-3-methylglutharyl-coenzyme A reductase (HMG-CoAR) expression and a good prognosis in breast cancer. Here, the predictive value of HMG-CoAR expression in relation to tamoxifen response was examined. METHODS:HMG-CoAR protein and RNA expr...

journal_title：Breast cancer research : BCR

authors： Brennan DJ,Laursen H,O'Connor DP,Borgquist S,Uhlen M,Gallagher WM,Pontén F,Millikan RC,Rydén L,Jirström K

更新日期：2011-01-31 00:00:00

abstract：INTRODUCTION:Aromatase inhibitor-associated arthralgia (AIAA) is a common and often debilitating symptom in breast cancer survivors. Since joint symptoms have been related to estrogen deprivation through the menopausal transition, we hypothesized that genetic polymorphisms in CYP19A1, the final enzyme in estrogen synth...

journal_title：Breast cancer research : BCR

authors： Mao JJ,Su HI,Feng R,Donelson ML,Aplenc R,Rebbeck TR,Stanczyk F,DeMichele A

更新日期：2011-01-20 00:00:00

abstract：:Epigenetic changes are critical for development and progression of cancers, including breast cancer. Significant progress has been made in the basic understanding of how various epigenetic changes such as DNA methylation, histone modification, miRNA expression, and higher order chromatin structure affect gene expressi...

journal_title：Breast cancer research : BCR

authors： Huang Y,Nayak S,Jankowitz R,Davidson NE,Oesterreich S

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Breast cancer is genetically and clinically a heterogeneous disease. However, the exact contribution of different cell types and oncogenic mutations to this heterogeneity are not well understood. Recently, we discovered an interaction between Wnt and integrin-linked kinase (ILK) within the signaling cascad...

journal_title：Breast cancer research : BCR

authors： Oloumi A,Maidan M,Lock FE,Tearle H,McKinney S,Muller WJ,Aparicio SA,Dedhar S

更新日期：2010-01-01 00:00:00

abstract：:Breast cancer is a heterogeneous disease with varied morphological appearances, molecular features, behavior, and response to therapy. Current routine clinical management of breast cancer relies on the availability of robust clinical and pathological prognostic and predictive factors to support clinical and patient de...

journal_title：Breast cancer research : BCR

authors： Rakha EA,Reis-Filho JS,Baehner F,Dabbs DJ,Decker T,Eusebi V,Fox SB,Ichihara S,Jacquemier J,Lakhani SR,Palacios J,Richardson AL,Schnitt SJ,Schmitt FC,Tan PH,Tse GM,Badve S,Ellis IO

更新日期：2010-01-01 00:00:00

abstract：:For the past 20 years the mouse has served as a workhorse for studying the molecular underpinnings of human breast cancer. While some genetically engineered mouse mammary tumor models do not accurately recapitulate human disease (that is, the MMTV-Neu model and HER2-overexpressing human cancers), additional tumor mode...

journal_title：Breast cancer research : BCR

authors： McDermott SP,Wicha MS

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The majority of breast cancers that occur in BRCA1 mutation carriers (BRCA1 carriers) are estrogen receptor-negative (ER-). Therefore, it has been suggested that ER negativity is intrinsic to BRCA1 cancers and reflects the cell of origin of these tumors. However, approximately 20% of breast cancers that de...

journal_title：Breast cancer research : BCR

authors： Tung N,Miron A,Schnitt SJ,Gautam S,Fetten K,Kaplan J,Yassin Y,Buraimoh A,Kim JY,Szász AM,Tian R,Wang ZC,Collins LC,Brock J,Krag K,Legare RD,Sgroi D,Ryan PD,Silver DP,Garber JE,Richardson AL

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The actin binding protein Mammalian enabled (Mena), has been implicated in the metastatic progression of solid tumors in humans. Mena expression level in primary tumors is correlated with metastasis in breast, cervical, colorectal and pancreatic cancers. Cells expressing high Mena levels are part of the tu...

journal_title：Breast cancer research : BCR

authors： Roussos ET,Wang Y,Wyckoff JB,Sellers RS,Wang W,Li J,Pollard JW,Gertler FB,Condeelis JS

更新日期：2010-01-01 00:00:00

abstract：:Accumulating evidence suggests that many cancers, including BRCA1- and BRCA2-associated breast cancers, are deficient in DNA repair processes. Both hereditary and sporadic breast cancers have been found to have significant downregulation of repair factors. This has provided opportunities to exploit DNA repair deficien...

journal_title：Breast cancer research : BCR

authors： Rowe BP,Glazer PM

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The purpose of this work was to study the prognostic influence in breast cancer of thioredoxin reductase 1 (TXNRD1) and thioredoxin interacting protein (TXNIP), key players in oxidative stress control that are currently evaluated as possible therapeutic targets. METHODS:Analysis of the association of TXNR...

journal_title：Breast cancer research : BCR

authors： Cadenas C,Franckenstein D,Schmidt M,Gehrmann M,Hermes M,Geppert B,Schormann W,Maccoux LJ,Schug M,Schumann A,Wilhelm C,Freis E,Ickstadt K,Rahnenführer J,Baumbach JI,Sickmann A,Hengstler JG

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Breast tumor kinase (Brk/protein tyrosine kinase 6 (PTK6)) is a nonreceptor, soluble tyrosine kinase overexpressed in the majority of breast tumors. Previous work has placed Brk downstream of epidermal growth factor receptor (ErbB) activation and upstream of extracellular signal-regulated kinase 5 (ERK5) a...

journal_title：Breast cancer research : BCR

authors： Castro NE,Lange CA

更新日期：2010-01-01 00:00:00

abstract：:Recent studies from Clarke's group published in the journal Cell indicate that miRNAs may be the elusive universal stem cell markers that the field of cancer stem cell biology has been seeking. Distinct profiles of miRNAs appear to reflect the state of cell differentiation not only in breast cancer cells, but also in ...

journal_title：Breast cancer research : BCR

authors： Dontu G,de Rinaldis E

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:17-allyamino-17-demethoxygeldanamycin (17-AAG), a small molecule inhibitor of Hsp90, is currently in clinical trials in breast cancer. However, 17-AAG treatment often results in inhibition of tumor growth rather than shrinkage, making detection of response a challenge. Magnetic resonance spectroscopy (MRS)...

journal_title：Breast cancer research : BCR

authors： Brandes AH,Ward CS,Ronen SM

更新日期：2010-01-01 00:00:00

abstract：:Immunohistochemistry is the most common method for companion diagnostic testing in breast cancer. The readings for estrogen receptor, progesterone receptor, and Her2 directly affect prescription of critical therapies. However, immunohistochemistry is highly sensitive to innumerable pre-analytic variables that result i...

journal_title：Breast cancer research : BCR

authors： Siddiqui S,Rimm DL

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:Triple-negative breast cancer does not express estrogen and progesterone receptors, and no overexpression/amplification of the HER2-neu gene occurs. Therefore, this subtype of breast cancer lacks the benefits of specific therapies that target these receptors. Today chemotherapy is the only systematic thera...

journal_title：Breast cancer research : BCR

authors： Gründker C,Föst C,Fister S,Nolte N,Günthert AR,Emons G

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:A family history of later-onset breast cancer (FHLBC) may suggest multi-factorial inheritance of breast cancer risk, including unhealthy lifestyle behaviors that may be shared within families. We assessed whether adherence to lifestyle behaviors recommended for breast cancer prevention--including maintaini...

journal_title：Breast cancer research : BCR

authors： Gramling R,Lash TL,Rothman KJ,Cabral HJ,Silliman R,Roberts M,Stefanick ML,Harrigan R,Bertoia ML,Eaton CB

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:During selective segregation of DNA, a cell asymmetrically divides and retains its template DNA. Asymmetric division yields daughter cells whose genome reflects that of the parents', simultaneously protecting the parental cell from genetic errors that may occur during DNA replication. We hypothesized that ...

journal_title：Breast cancer research : BCR

authors： Bussard KM,Boulanger CA,Kittrell FS,Behbod F,Medina D,Smith GH

更新日期：2010-01-01 00:00:00